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For patients whose prior B12 supplementation hasn't worked, injection is the solution not a higher oral dose

The exact product, concentration, route, and quantity should follow clinician directions

Because it can absorb up to 50 times its weight in water, its used as a weight loss supplement to increase fullness and reduce appetite ( How it works: Glucomannan is understood to encourage weight loss by reducing appetite, increasing feelings of fullness, slowing digestion and blocking the absorption of fat and protein ( Effectiveness: Studies on glucomannans impact on weight loss have provided inconsistent findings

It's actually working exactly as designed, but it's responding to the wrong signal

Clinical trials specifically using the arginate formulation would provide human pharmacokinetic data and efficacy endpoints